New paper shows that
when exposed to the MERS Coronavirus (CoV) bat cells adapt—not by producing
inflammation-causing proteins but rather by maintaining a natural antiviral
response. Simultaneously, the MERS virus also adapts to the bat host cells by
very rapidly mutating one specific gene. Operating together, these adaptations
result in the virus remaining long-term in the bat but being rendered harmless.
Instead of killing bat cells as the virus does with human cells, the MERS
coronavirus enters a long-term relationship with the host, maintained by the
bat’s unique ‘super’ immune system. SARS-CoV-2 is thought to operate in the
same way. The work suggests that stresses on bats—such as wet markets, other
diseases, and possibly habitat loss—may have a role in coronavirus spilling
over to other species.
This article in Scientific American points out that three-quarters of the emerging pathogens that infect humans leaped from animals, many of the creatures in the forest habitats that we are slashing and burning to create land for crops, including biofuel plants, and for mining and housing. The more we clear, the more we come into contact with wildlife that carries microbes well suited to kill us—and the more we concentrate those animals in smaller areas where they can swap infectious microbes, raising the chances of novel strains.
A pre-print of the results of a study of 386 coronavirus patients in a US government hospital for military veterans found more deaths among those treated with hydroxychloroquine than those treated with standard care. These findings highlight the importance of awaiting the results of ongoing prospective, randomized, controlled studies before widespread adoption of this drug, say the authors of the study.
This is an article in National Geographic and not a scientific paper but it shows with graphs and a lot of references that social distancing isn’t a new idea and it saved thousands of American lives during the last great pandemic in 1918.
New evidence has emerged from China indicating that the large
majority of coronavirus infections do not result in symptoms. Experts say that
it was quite likely that the virus had been circulating for longer than
generally believed and that large swathes of the population had already been
New important research shows early ‘evolutionary paths’ of COVID-19 in humans – as the infection spread from Wuhan out to Europe and North America – using genetic network techniques. The research revealed three distinct ‘variants’ of COVID-19, consisting of clusters of closely related lineages, which they label ‘A’, ‘B’ and ‘C’. Variant ‘A’, most closely related to the virus found in both bats and pangolins, is described as ‘the root of the outbreak’. Type ‘B’ is derived from ‘A’, separated by two mutations, then ‘C’ is in turn a “daughter” of ‘B’.
New genetic analysis of
SARS-CoV-2 and related coronaviruses suggests the ancestor of
COVID-19 and its nearest relative — a bat coronavirus — infected the intestine
of dogs, most likely resulting in a rapid evolution of the virus and its jump
into humans. This suggests the importance of monitoring SARS-like coronaviruses
in feral dogs. It is to be noted however that other experts have doubts.
Paper shows that wild mammals that were at risk of extinction owing to human activities carried twice the zoonotic diseases compared to animals that were not at the same risk. Among threatened wildlife species, those with population reductions owing to exploitation and loss of habitat shared more viruses with humans. This has increased opportunities for animal-human interactions and facilitated zoonotic-disease transmission.
Link to article: https://royalsocietypublishing.org/doi/10.1098/rspb.2019.2736
How does COVID-19 kill? Uncertainty over whether it is the virus itself — or the response by a person’s immune system — that ultimately overwhelms a patient’s organs, is making it difficult for doctors to determine the best way to treat patients who are critically ill with the coronavirus. Clinical data suggest that the immune system plays a part in the decline and death of people infected with the new coronavirus, and this has spurred a push for treatments such as steroids that rein in that immune response. But some of these treatments act broadly to suppress the immune system.
antibody recovered from a survivor of the SARS epidemic in the early 2000s has
revealed a potential vulnerability of the new coronavirus at the root of
Published in Science, the study is the first to map a human antibody’s interaction with the new coronavirus at near-atomic-scale resolution. Although the antibody was produced in response to an infection of SARS, which is caused by the SARS-CoV virus, it cross-reacts with the new coronavirus, SARS-CoV-2.
Cats can be infected with COVID-19 and can spread it to other cats, but dogs are not really susceptible to the infection, say researchers in China. The team, at Harbin Veterinary Research Institute, also concludes that chickens, pigs, and ducks are not likely to catch the virus. Other scientists say the findings are interesting but note the results are based on lab experiments in which a small number of animals were deliberately given high doses of the virus, SARS-CoV-2, and do not represent real-life interactions between people and their pets.
Disinformation and misinformation around COVID-19 continue to proliferate around the world, with potentially harmful consequences for public health and effective crisis communication. In the EU and elsewhere, coordinated disinformation messaging seeks to frame vulnerable minorities as the cause of the pandemic and to fuel distrust in the ability of democratic institutions to deliver effective responses.
Comparison of face mask use recommendations by different health authorities. Despite the consistency in the recommendation that symptomatic individuals and those in health-care settings should use face masks, differences in recommendations were observed for the general public and community settings. Evidence that face masks can provide effective protection against respiratory infections in the community is scarce. However, face masks are widely used by medical workers as part of droplet precautions when caring for patients with respiratory infections. The study suggests vulnerable individuals avoid crowded areas and use surgical face masks rationally when exposed to high-risk areas.
In this pre-print a team from Harvard using mathematical model found that one-time interventions will be insufficient to maintain COVID-19 prevalence within the critical care capacity of the United States. Seasonal variation in transmission will facilitate epidemic control during the summer months but could lead to an intense resurgence in the autumn. Intermittent distancing measures can maintain control of the epidemic, but without other interventions, these measures may be necessary into 2022.
This study analyzed l data from 311 regions across 116 countries with reported cases of COVID-19 by March 12, 2020, and found that temperature, humidity, and wind speed were inversely associated with the incidence rate of Covid-19. This means that it is likely that as temperature, humidity and wind speed increase the spread of COVID-19 decreases.
The authors have built human mobility models, for which they are experts, and attach a virus infection dynamics to it. This results in a virus spreading dynamics model. The preliminary model shows that complete lockdown works. About 10 days after lockdown, the infection dynamics die down in the model. Infections in public transport play an important role, they say. The simulations say that complete removal of infections at child care, primary schools, workplaces and during leisure activities will not be enough to sufficiently slow down the infection dynamics.
This study formulates a conceptual mathematical model on the transmission dynamics of COVID-19 between the frontliners (e.g. healthcare workers, customer service and retail personnel, food service crews) and the general public. The take-home message of this preliminary model is that everyone in the community, whether a frontliner or not, should be protected or should implement preventive measures to avoid being infected.
This is a systematic literature review summarizing the available evidence regarding the role of chloroquine in treating coronavirus infection. It says there is theoretical, experimental, preclinical and clinical evidence of the effectiveness of chloroquine in patients affected with COVID-19. There is adequate evidence of drug safety from the long-time clinical use of chloroquine and hydroxychloroquine in other indications. More data from ongoing and future trials will add more insight into the role of chloroquine and hydroxychloroquine in COVID-19 infection it concludes.
There are several genetic strains of COVID-19 circulating around the world. Information is found on NextStrain, an online resource for scientists that uses data from academic, independent and government laboratories all over the world to visually track the genomics of the SARS-CoV-2 virus. It currently represents genetic sequences of strains from 36 countries on six continents.
A wide-ranging study points out that simple public health measures seem to be highly effective at reducing the transmission of respiratory viruses. It recommends implementing the following interventions: frequent handwashing (with or without antiseptics), barrier measures (gloves, gowns, and masks), and isolation of people with suspected respiratory tract infections.
The authors are of the opinion that evidence regarding the complete loss of smell, or anosmia and the loss of taste or dysgeusia in people who had no other symptoms but who tested positive for COVID-19 are mostly anecdotal and therefore should be treated as preliminary and with caution.
Link to article: https://www.cebm.net/covid-19/what-is-the-evidence-for-anosmia-loss-of-smell-as-a-clinical-feature-of-covid-19/
A new paper, 26 March, describes multiple lineages of pangolin coronavirus and their similarity to the SARS-CoV-2. A previous study had suggested that Pangolins could be intermediate hosts. Although bats are likely reservoir hosts for SARS-CoV-2, this study says that pangolins should be considered as possible hosts in the emergence of novel coronaviruses and should be removed from wet markets to prevent zoonotic transmission. The study was done on Malayan pangolins (Manis javanica) seized in anti-smuggling operations in southern China. Pangolins are the world’s most trafficked animals.
Prof Paul Hunter, Professor in Medicine, University of East Anglia, U.K, talks to the Science Media Centre on whether its advisable expert to have sex while either socially distancing or self-isolating with symptoms.
Mutation. The word naturally conjures fears of unexpected and freakish changes. Ill-informed discussions of mutations thrive during virus outbreaks, including the ongoing spread of SARS-CoV-2. In reality, mutations are a natural part of the virus life cycle and rarely impact outbreaks dramatically say virologists writing in the journal Nature Microbiology.
Viruses are kind of mysterious – there is debate on whether on not they are “alive”. At a basic level, viruses are proteins and genetic material that survive and replicate within their environment, inside another life form. In the absence of their host, viruses are unable to replicate and many are unable to survive for long outside the host. Therefore, if they cannot survive independently, can they be defined as being ‘alive’? Taking opposing views, two microbiologists discuss how viruses fit with the concept of being ‘alive’ and how they should be defined.
An article from the publishers of Science on 22 March on WHO megatrials. WHO is focusing on what it says are the four most promising therapies: an experimental antiviral compound called remdesivir; the malaria medications chloroquine and hydroxychloroquine; a combination of two HIV drugs, lopinavir, and ritonavir; and that same combination plus interferon-beta, an immune system messenger that can help cripple viruses.
A popular article from the publishers of Nature describing ongoing research that hopes that the antibody-laden blood of those who have recovered from coronavirus might reduce severe infections. It is as yet unknown if it will work.
Review identifies 1415 species of infectious organism known to be pathogenic to humans. Out of these, 868 (61%) are zoonotic, that is, they can be transmitted between humans and animals, and 175 pathogenic species are associated with diseases considered to be ’emerging’. Out of the emerging pathogens, 132 (75%) are zoonotic.
March 17, 2020. A clinical trial of investigational vaccine for COVID-19 has begun. Phase 1 clinical trial evaluating an investigational vaccine designed to protect against coronavirus disease 2019 (COVID-19) has begun at Kaiser Permanente Washington Health Research Institute (KPWHRI) in Seattle. Currently (March 17, 2020) no approved vaccines exist to prevent infection with SARS-CoV-2.
While many of us are social distancing and self-quarantining, we have a lot of time to wonder, how did we get in this coronavirus mess in the first place? The answer is a zoonotic disease – a disease that can leap from animal to human. In order to prevent future pandemics, we need to change our relationship with wildlife. So what does that mean exactly?
More than 800 cases of laboratory-confirmed COVID-19 cases occurred during outbreaks on three cruise ship voyages, and cases linked to several additional cruises have been reported across the United States. Transmission occurred across multiple voyages from ship to ship by crew members; both crew members and passengers were affected; 10 deaths associated with cruise ships have been reported to date.
A new study shows people with blood group A have a significantly higher risk for acquiring COVID-19 whereas blood group O has a significantly lower risk for the infection. However, the paper has not been peer-reviewed yet. This means it has yet to be evaluated and so should not be used to guide clinical practice or to promote the results.
The World Organisation for Animal Health says that there have not been any reports of pets presenting clinical signs caused by COVID-19 virus infection and currently there is no evidence that they play a significant epidemiological role in this disease.
Asian Pangolin species, the worlds most traded wild animals, are Critically
Endangered because of illegal trade. Now the species which may be the
intermediate host of COVID-19 is in even more danger as panic killing may wipe
This article describes the Mental Health and Faith Community Partnership which is a collaboration between psychiatrists and clergy. The partnership provides an opportunity for psychiatrists and the mental health community to learn from spiritual leaders, to whom people often turn in times of mental distress. At the same time, it provides an opportunity to improve understanding of the best science and evidence-based treatment for psychiatric illnesses among faith leaders and those in the faith community.
Decisions on how to apply quarantine should be based on the best available evidence. This paper reviews the psychological impact of quarantine using three electronic databases. Results show that in situations where quarantine is deemed necessary, officials should quarantine individuals for no longer than required, provide a clear rationale for quarantine and information about protocols, and ensure sufficient supplies are provided.
The data confirms that some infected people “can be highly contagious when they have mild or no symptoms. Urgent measures are needed to curb mild and asymptomatic cases that are fuelling the pandemic. This bolsters the case for closing schools, cancelling public gatherings and generally keeping people at home and out of public spaces.
Shows Taiwan as an example of how a society can respond quickly to a crisis and protect the interests of its citizens. Taiwan’s government learned from its 2003 SARS experience and established a public health response mechanism for enabling rapid actions for the next crisis. Well-trained and experienced teams of officials were quick to recognize the COVID-19 crisis and activated emergency management structures to address the emerging outbreak.
Time magazine interviews Dr. Bruce Aylward, the senior adviser to the Director-General of the WHO, is one of the world’s top officials in charge of fighting the coronavirus pandemic. Dr. Aylward has almost 30 years of experience in fighting polio, Ebola and other diseases, and now he’s turned his attention to stopping the spread of COVID-19.
In the case of the 1918 flu pandemic, research has shown that the faster authorities moved to implement the kinds of social distancing measures designed to slow the transmission of disease, the more lives were saved.
Not a peer-reviewed paper but we deem it useful and interesting. It explores how strong coronavirus measures today should only last a few weeks, there shouldn’t be a big peak of infections afterward, and it can all be done for a reasonable cost to society, saving millions of lives along the way.