The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro

Study showed that a single dose of the drug, Ivermectin, could stop the SARS-CoV-2 virus growing in cell culture – effectively eradicating all genetic material of the virus within 48 hours. Ivermectin is an anti-parasitic drug that has also been shown to be effective in vitro against a broad range of viruses including HIV, Dengue, Influenza and Zika virus.

Link to study: https://www.sciencedirect.com/science/article/pii/S0166354220302011

Role of Chloroquine and Hydroxychloroquine in the Treatment of COVID-19 Infection- A Systematic Literature Review | medRxiv

This is a systematic literature review summarizing the available evidence regarding the role of chloroquine in treating coronavirus infection. It says there is theoretical, experimental, preclinical and clinical evidence of the effectiveness of chloroquine in patients affected with COVID-19. There is adequate evidence of drug safety from the long-time clinical use of chloroquine and hydroxychloroquine in other indications. More data from ongoing and future trials will add more insight into the role of chloroquine and hydroxychloroquine in COVID-19 infection it concludes.

Link to article: https://www.medrxiv.org/content/10.1101/2020.03.24.20042366v1

WHO launches global megatrial of the four most promising coronavirus treatments

An article from the publishers of Science on 22 March on WHO megatrials. WHO is focusing on what it says are the four most promising therapies: an experimental antiviral compound called remdesivir; the malaria medications chloroquine and hydroxychloroquine; a combination of two HIV drugs, lopinavir, and ritonavir; and that same combination plus interferon-beta, an immune system messenger that can help cripple viruses. 

Link to article: https://www.sciencemag.org/news/2020/03/who-launches-global-megatrial-four-most-promising-coronavirus-treatments

Twitter thread on Chloroquine (CQ) and Hydroxychloroquine (HCQ) by Dr. Gaetan Burgio

Unusually, we include a Twitter feed here as it represents a good analysis of the efficacy of the antimalarial drug chloroquine as a treatment for COVID-19. It is from Dr. Gaetan Burgio, a geneticist at the Australian National University who dug into the available & published data and reveals that as of this date the evidence remains anecdotal and a clinical trial is incomplete and not following scientific rigour. More research is needed.

Link to Twitter thread: https://twitter.com/GaetanBurgio/status/1241201751916568576

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