Study showed that a single dose of the drug, Ivermectin, could stop the SARS-CoV-2 virus growing in cell culture – effectively eradicating all genetic material of the virus within 48 hours. Ivermectin is an anti-parasitic drug that has also been shown to be effective in vitro against a broad range of viruses including HIV, Dengue, Influenza and Zika virus.
This is a systematic literature review summarizing the available evidence regarding the role of chloroquine in treating coronavirus infection. It says there is theoretical, experimental, preclinical and clinical evidence of the effectiveness of chloroquine in patients affected with COVID-19. There is adequate evidence of drug safety from the long-time clinical use of chloroquine and hydroxychloroquine in other indications. More data from ongoing and future trials will add more insight into the role of chloroquine and hydroxychloroquine in COVID-19 infection it concludes.
Link to article: https://www.medrxiv.org/content/10.1101/2020.03.24.20042366v1
An article from the publishers of Science on 22 March on WHO megatrials. WHO is focusing on what it says are the four most promising therapies: an experimental antiviral compound called remdesivir; the malaria medications chloroquine and hydroxychloroquine; a combination of two HIV drugs, lopinavir, and ritonavir; and that same combination plus interferon-beta, an immune system messenger that can help cripple viruses.
Unusually, we include a Twitter feed here as it represents a good analysis of the efficacy of the antimalarial drug chloroquine as a treatment for COVID-19. It is from Dr. Gaetan Burgio, a geneticist at the Australian National University who dug into the available & published data and reveals that as of this date the evidence remains anecdotal and a clinical trial is incomplete and not following scientific rigour. More research is needed.
Link to Twitter thread: https://twitter.com/GaetanBurgio/status/1241201751916568576
A popular article from the publishers of Nature describing ongoing research that hopes that the antibody-laden blood of those who have recovered from coronavirus might reduce severe infections. It is as yet unknown if it will work.
Link to article: https://www.nature.com/articles/d41586-020-00895-8
A discussion of whether hydroxychloroquine and azithromycin are an effective treatment for COVID-19 based on the latest research and knowledge.
At least six clinical trials for hydroxychloroquine are recruiting patients or in planning stages around the world.
Nearly 70 drugs and experimental compounds may be effective in treating the coronavirus, a team of researchers reported. To come up with the list, hundreds of researchers embarked on an unusual study of the genes of the coronavirus, also called SARS-CoV-2.
Link to article: https://www.biorxiv.org/content/10.1101/2020.03.22.002386v1