Structural basis of RNA cap modification by SARS-CoV-2

A new treatment idea for COVID-19 is possible after the discovery of the reason why the virus is so dangerous.  The pathogen camouflages itself after infecting cells to prevent a swift response from the immune system. An enzyme the virus produces that tricks cells into believing the viral RNA belongs there has been identified. This mechanism delays the immune response and allows the virus to replicate inside cells. Therapies targeting the enzyme could prevent the pathogen from hiding in plain sight.

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